NANOHER2RESTORE

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A few words about NANOHER2RESTORE

Project name: “Restore Her2 dependent sensibility using AXL inhibitors packed in pH dependent nanostructures”, project code EEA-RO-NO-2018-0246, acronym NANOHER2RESTORE

”Project funded under the Research Programme associated with the EEA Financial Mechanism (EEA Grants) and administered by UEFISCDI as Programme Operator.”

”Working together for a green, competitive and inclusive Europe”

- the implementation period ended on April 30, 2024

- total funding EUR 1,177,533

- EEA fund granting 1000903 EUR

- public national co-funding EUR 176,630  

Project infoProject info

a-few-words-about-nanoher2restore
 

NANOHER2RESTORE

This project proposes to apply modular supramolecular assembly consisting of pH sensitive units, recognition moieties and functional molecules to build up therapeutic entities sensitive to the tumour microenvironment and to investigate mechanisms for targeted breast cancer treatment in vitro and in vivo.

Results

 

EEA GRANTS

”Project funded under the Research Programme associated with the EEA Financial Mechanism (EEA Grants) and administered by UEFISCDI as Programme Operator.”

 

PROJECT PROMOTER

The promoter of the NANOHER2RESTORE project is Regional Institute of Oncology from Iasi, Romania

 
 

OBJECTIVES

O1. Produce and characterize a pH-dependent micellar assembly of functionalized copolymer blocks and targeted delivery of AXL inhibitor to target Her positive breast cancer tumors.
O2. Produce a range of complex functionalized and loaded nanostructured assemblies with different pH stability.
O3. Study in vitro biological interactions between simple/functionalized nanostructured micelles and appropriate breast cancer (BC) cell lines.
All objectivesAll objectives

The created NANOHER2RESTORE interdisciplinary and international consortium represents a well-balanced team of three university research groups with different but very complementary research approaches

Iasi Regional Institute of Oncology
7
researchers
“Petru Poni” Institute of Macromolecular Chemistry
6
researchers
Oslo University
Hospital
9
researchers

The EEA and Norway Grants represent the contribution of Iceland, Liechtenstein and Norway towards a green, competitive and inclusive Europe. There are two overall objectives: reduction of economic and social disparities in Europe, and to strengthen bilateral relations between the donor countries and 15 EU countries in Central and Southern Europe and the Baltics.

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contact@nanoher2restore.ro
Str. General Henri Mathias Berthelot, Nr. 2-4
Iasi, Romania